Selective microRNA Suppression in Human Thoracic Aneurysms: Relationship of miR-29a to Aortic Size and Proteolytic Induction Short title: Jones et al.; miRNA Expression in Thoracic Aortic Aneurysm
نویسندگان
چکیده
Cardiothoracic Surgery Research, Division of Cardiothoracic Surgery, Medical University of South Carolina; Ralph H. Johnson Veterans Affairs Medical Center, Research Service; Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC; Department of Cardiothoracic Surgery, Yale University School of Medicine, New Haven, CT; Gorman Cardiovascular Research Group, Glenolden Research
منابع مشابه
Selective microRNA suppression in human thoracic aneurysms: relationship of miR-29a to aortic size and proteolytic induction.
BACKGROUND Increasing evidence points to a direct role for altered microRNA (miRNA or miR) expression levels in cardiovascular remodeling and disease progression. Although alterations in miR expression levels have been directly linked to cardiac hypertrophy, fibrosis, and remodeling, their role in regulating gene expression during thoracic aortic aneurysm (TAA) development has yet to be explore...
متن کاملAneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms
Altered microRNA expression is implicated in cardiovascular diseases. Our objective was to determine microRNA signatures in thoracic aortic aneurysms (TAAs) and abdominal aortic aneurysms (AAAs) compared with control non-aneurysmal aortic specimens. We evaluated the expression of fifteen selected microRNA in human TAA and AAA operative specimens compared to controls. We observed significant upr...
متن کاملMycotic aortic aneurysm as a postsurgical complication: report of a case and review of the literature
Mycotic aneurysms are localized and irreversible dilatations of the arteries caused by weakening and damaging the arterial wall by an invasive organism establishing infective arteritis. Mycotic aneurysm of the thoracic aorta is a rare event; however, it can be fatal if not diagnosed early or not treated appropriately. Clinical findings are usually nonspecific; however, c...
متن کاملModulating the MicroRNArchitecture of an aging aorta.
The 17th century British physician Thomas Sydenham is credited with saying, “A man is as old as his arteries.” Indeed, aging is associated with myriad structural and functional changes in the cardiovascular system.1 In particular, thoracic aortic aneurysms are commonly found in people during the sixth or seventh decade of life and at a frequency of nearly 1 in 16 000 people per year.2 An aneury...
متن کاملA Preliminary microRNA Analysis of Non Syndromic Thoracic Aortic Aneurysms
The development of thoracic aortic aneurysms (TAAs) involves a multifactorial process resulting in alterations of the structure and composition of the extracellular matrix (ECM). Recently, modifications in microRNA (miRNA) expression were implicated in the pathogenesis of TAA. This study presents a preliminary miRNA microarray analysis conducted on pooled ascending aorta RNAs obtained from non ...
متن کامل